Ontology highlight
ABSTRACT:
SUBMITTER: Carey M
PROVIDER: S-EPMC5652610 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Carey Michelle M Gospin Rebekah R Goyal Akankasha A Tomuta Nora N Sandu Oana O Mbanya Armand A Lontchi-Yimagou Eric E Hulkower Raphael R Shamoon Harry H Gabriely Ilan I Hawkins Meredith M
Diabetes 20170831 11
Although intensive glycemic control improves outcomes in type 1 diabetes mellitus (T1DM), iatrogenic hypoglycemia limits its attainment. Recurrent and/or antecedent hypoglycemia causes blunting of protective counterregulatory responses, known as hypoglycemia-associated autonomic failure (HAAF). To determine whether and how opioid receptor activation induces HAAF in humans, 12 healthy subjects without diabetes (7 men, age 32.3 ± 2.2 years, BMI 25.1 ± 1.0 kg/m<sup>2</sup>) participated in two stud ...[more]