Ontology highlight
ABSTRACT:
SUBMITTER: Fabris V
PROVIDER: S-EPMC5653926 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Fabris Victoria V Abascal María F MF Giulianelli Sebastián S May María M Sequeira Gonzalo R GR Jacobsen Britta B Lombès Marc M Han Julie J Tran Luan L Molinolo Alfredo A Lanari Claudia C
The journal of pathology. Clinical research 20171010 4
Progesterone receptors (PR) are prognostic and predictive biomarkers in hormone-dependent cancers. Two main PR isoforms have been described, PRB and PRA, that differ only in that PRB has 164 extra N-terminal amino acids. It has been reported that several antibodies empirically exclusively recognize PRA in formalin-fixed paraffin-embedded (FFPE) tissues. To confirm these findings, we used human breast cancer xenograft models, T47D-YA and -YB cells expressing PRA or PRB, respectively, MDA-MB-231 c ...[more]