Ontology highlight
ABSTRACT:
SUBMITTER: Hai L
PROVIDER: S-EPMC6141023 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Hai Lan L Szwarc Maria M MM Wetendorf Margeaux M Wu San-Pin SP Peavey Mary C MC Grimm Sandra L SL Edwards Dean P DP DeMayo Francesco J FJ Lydon John P JP
Genesis (New York, N.Y. : 2000) 20180810 8
Using a Rosa26 gene targeting strategy in mouse embryonic stem cells, we have generated a new transgenic mouse (Pgr-B <sup>LSL</sup> ), which is designed to conditionally express the epitope-tagged mouse progesterone receptor-B (PGR-B) isoform when crossed with a specific cre driver mouse. To functionally validate this transgenic mouse, we crossed the Pgr-B <sup>LSL</sup> mouse with the MMTV-CREA transgenic mouse to create the MMTV-CREA/Pgr-B <sup>LSL</sup> bigenic (termed PR-B:OE to denote PGR- ...[more]