Progesterone through Progesterone Receptor B Isoform Promotes Rodent Embryonic Oligodendrogenesis.

ABSTRACT: Oligodendrocytes are the myelinating cells of the central nervous system (CNS). These cells arise during the embryonic development by the specification of the neural stem cells to oligodendroglial progenitor cells (OPC); newly formed OPC proliferate, migrate, differentiate, and mature to myelinating oligodendrocytes in the perinatal period. It is known that progesterone promotes the proliferation and differentiation of OPC in early postnatal life through the activation of the intracellular progesterone receptor (PR). Progesterone supports nerve myelination after spinal cord injury in adults. However, the role of progesterone in embryonic OPC differentiation as well as the specific PR isoform involved in progesterone actions in these cells is unknown. By using primary cultures obtained from

SUBMITTER: Gonzalez-Orozco JC 

PROVIDER: S-EPMC7226962 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature