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Genomic Characterization of VIM Metallo-?-Lactamase-Producing Alcaligenes faecalis from Gaza, Palestine.

ABSTRACT: Carbapenemase-producing Gram-negative bacteria (CP-GNB) have increasingly spread worldwide, and different families of carbapenemases have been identified in various bacterial species. Here, we report the identification of five VIM metallo-?-lactamase-producing Alcaligenes faecalis isolates associated with a small outbreak in a large hospital in Gaza, Palestine. Next-generation sequencing analysis showed blaVIM-2 is harbored by a chromosomal genomic island among three strains, while blaVIM-4 is carried by a novel plasmid in two strains.

SUBMITTER: Al Laham N

PROVIDER: S-EPMC5655106 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Genomic Characterization of VIM Metallo-β-Lactamase-Producing Alcaligenes faecalis from Gaza, Palestine.

Al Laham Nahed N Chavda Kalyan D KD Cienfuegos-Gallet Astrid V AV Kreiswirth Barry N BN Chen Liang L

Antimicrobial agents and chemotherapy 20171024 11

Carbapenemase-producing Gram-negative bacteria (CP-GNB) have increasingly spread worldwide, and different families of carbapenemases have been identified in various bacterial species. Here, we report the identification of five VIM metallo-β-lactamase-producing Alcaligenes faecalis isolates associated with a small outbreak in a large hospital in Gaza, Palestine. Next-generation sequencing analysis showed blaVIM-2 is harbored by a chromosomal genomic island among three str ...[more]

PMID: 28848020

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