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Escherichia coli ST471 Producing VIM-4 Metallo-β-Lactamase in Colombia.

ABSTRACT: An Escherichia coli isolate sequence-type 471 (ST471) producing Verona integron-encoded metallo-β-lactamases (VIM)-4 was recovered from a rectal swab in a patient without travel records with osteomyelitis in Colombia. The isolate carried a class 1 integron-borne blaVIM-4 gene with a 170-bp duplication in the 3' end of the gene, preceded by an aac(6')-Ib gene. The genetic environment of blaVIM-4, blaCMY-2, and sul2 genes showed similarities to the backbone of pKKp4, an IncA/C-type plasmid from a Klebsiella pneumoniae strain carrying blaVIM-4 recovered in Kuwait. This is the first report of blaVIM-4 in Enterobacterales in South America. Our results suggest that blaVIM-4 gene was found on an IncA/C-type plasmid that could play a role in the spread of VIM-4 carbapenemase in Colombia.

SUBMITTER: Rada AM 

PROVIDER: S-EPMC8968847 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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<i>Escherichia coli</i> ST471 Producing VIM-4 Metallo-β-Lactamase in Colombia.

Rada Ana Mercedes AM   Correa Adriana A   Restrepo Eliana E   Capataz Cesar C  

Microbial drug resistance (Larchmont, N.Y.) 20220104 3

An <i>Escherichia coli</i> isolate sequence-type 471 (ST471) producing Verona integron-encoded metallo-β-lactamases (VIM)-4 was recovered from a rectal swab in a patient without travel records with osteomyelitis in Colombia. The isolate carried a class 1 integron-borne <i>bla</i><sub>VIM-4</sub> gene with a 170-bp duplication in the 3' end of the gene, preceded by an <i>aac(6</i>')-Ib gene. The genetic environment of <i>bla</i><sub>VIM-4</sub>, <i>bla</i><sub>CMY-2</sub>, and <i>sul2</i> genes s  ...[more]

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