Ontology highlight
ABSTRACT:
SUBMITTER: Wieteska L
PROVIDER: S-EPMC5655141 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Wieteska Lukasz L Shahidi Saeid S Zhuravleva Anastasia A
eLife 20171024
BiP is the only Hsp70 chaperone in the endoplasmic reticulum (ER) and similar to other Hsp70s, its activity relies on nucleotide- and substrate-controllable docking and undocking of its nucleotide-binding domain (NBD) and substrate-binding domain (SBD). However, little is known of specific features of the BiP conformational landscape that tune BiP to its unique tasks and the ER environment. We present methyl NMR analysis of the BiP chaperone cycle that reveals surprising conformational heterogen ...[more]