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Post-translational regulation of macrophage migration inhibitory factor: Basis for functional fine-tuning.

ABSTRACT: Macrophage migration inhibitory factor (MIF) is a chemokine-like protein and an important mediator in the inflammatory response. Unlike most other pro-inflammatory cytokines, a number of cell types constitutively express MIF and secretion occurs from preformed stores. MIF is an evolutionarily conserved protein that shows a remarkable functional diversity, including specific binding to surface CD74 and chemokine receptors and the presence of two intrinsic tautomerase and oxidoreductase activities. Several studies have shown that MIF is subject to post-translational modification, particularly redox-dependent modification of the catalytic proline and cysteine residues. In this review, we summarize and discuss MIF post-translational modifications and their effects on the biological properties of this protein. We propose that the redox-sensitive residues in MIF will be modified at sites of inflammation and that this will add further depth to the functional diversity of this intriguing cytokine.

SUBMITTER: Schindler L

PROVIDER: S-EPMC5975065 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Post-translational regulation of macrophage migration inhibitory factor: Basis for functional fine-tuning.

Schindler Lisa L Dickerhof Nina N Hampton Mark B MB Bernhagen Jürgen J

Redox biology 20171206

Macrophage migration inhibitory factor (MIF) is a chemokine-like protein and an important mediator in the inflammatory response. Unlike most other pro-inflammatory cytokines, a number of cell types constitutively express MIF and secretion occurs from preformed stores. MIF is an evolutionarily conserved protein that shows a remarkable functional diversity, including specific binding to surface CD74 and chemokine receptors and the presence of two intrinsic tautomerase and oxidoreductase activities ...[more]

PMID: 29247897

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Dataset Information

Post-translational regulation of macrophage migration inhibitory factor: Basis for functional fine-tuning.

Publications

Post-translational regulation of macrophage migration inhibitory factor: Basis for functional fine-tuning.

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