Ontology highlight
ABSTRACT:
SUBMITTER: Griffith AA
PROVIDER: S-EPMC6747426 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Griffith Alijah A AA Holmes William W
International journal of molecular sciences 20190828 17
The discovery of heat shock proteins shaped our view of protein folding in the cell. Since their initial discovery, chaperone proteins were identified in all domains of life, demonstrating their vital and conserved functional roles in protein homeostasis. Chaperone proteins maintain proper protein folding in the cell by utilizing a variety of distinct, characteristic mechanisms to prevent aberrant intermolecular interactions, prevent protein aggregation, and lower entropic costs to allow for pro ...[more]