Ontology highlight
ABSTRACT:
SUBMITTER: Gai W
PROVIDER: S-EPMC5657058 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Gai Weiwei W Zheng Xuexing X Wang Chong C Wang Hualei H Zhao Yongkun Y Wang Qi Q Wong Gary G Zhang Weijiao W Feng Na N Qiu Boning B Chi Hang H Li Nan N Wang Tiecheng T Gao Yuwei Y Shan Junjie J Yang Songtao S Xia Xianzhu X
Virology journal 20171025 1
<h4>Background</h4>Marburg virus (MARV) causes severe haemorrhagic fever in humans and nonhuman primates and has a high mortality rate. However, effective drugs or licensed vaccines are not currently available to control the outbreak and spread of this disease.<h4>Methods</h4>In this study, we generated MARV virus-like particles (VLPs) by co-expressing the glycoprotein (GP) and matrix protein (VP40) using the baculovirus expression system. MARV VLPs and three adjuvants, Poria cocos polysaccharid ...[more]