Ontology highlight
ABSTRACT:
SUBMITTER: Yi P
PROVIDER: S-EPMC5657569 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Yi Ping P Wang Zhao Z Feng Qin Q Chou Chao-Kai CK Pintilie Grigore D GD Shen Hong H Foulds Charles E CE Fan Guizhen G Serysheva Irina I Ludtke Steven J SJ Schmid Michael F MF Hung Mien-Chie MC Chiu Wah W O'Malley Bert W BW
Molecular cell 20170824 5
Nuclear receptors recruit multiple coactivators sequentially to activate transcription. This "ordered" recruitment allows different coactivator activities to engage the nuclear receptor complex at different steps of transcription. Estrogen receptor (ER) recruits steroid receptor coactivator-3 (SRC-3) primary coactivator and secondary coactivators, p300/CBP and CARM1. CARM1 recruitment lags behind the binding of SRC-3 and p300 to ER. Combining cryo-electron microscopy (cryo-EM) structure analysis ...[more]