Ontology highlight
ABSTRACT:
SUBMITTER: Teto G
PROVIDER: S-EPMC5658410 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Teto Georges G Tagny Claude T CT Mbanya Dora D Fonsah Julius Y JY Fokam Joseph J Nchindap Emilienne E Kenmogne Léopoldine L Njamnshi Alfred K AK Kanmogne Georgette D GD
Scientific reports 20171026 1
In HIV-1 subtype-B, specific mutations in Gag cleavage sites (CS) are associated with treatment failure, with limited knowledge among non-B subtypes. We analyzed non-B HIV-1 gag and pol (protease/reverse-transcriptase) sequences from Cameroonians for drug resistance mutations (DRMs) in the gag P2/NC CS, and pol major DRMs. Phylogeny of the 141 sequences revealed a high genetic diversity (12 subtypes): 67.37% CRF02_AG versus 32.6% non-CRF02_AG. Overall, 7.3% transmitted and 34.3% acquired DRMs we ...[more]