Dataset Information

Association between TNF-?-238G/A gene polymorphism and OCD susceptibility: A meta-analysis.

ABSTRACT: Tumor necrosis factor-alpha (TNF-?) is an important cytokine and has been reported to be associated with the pathogenesis of many autoimmune and inflammatory diseases. TNF-? gene is located on a region that has been found to be associated with obsessive-compulsive disorder (OCD). We performed this meta-analysis to assess the relationship between susceptibility to OCD and the TNF-?-238G/A gene polymorphism.An extensive search of the available literature on the association between the susceptibility to OCD and the TNF gene polymorphism was conducted by searching PubMed, Web of Knowledge, Embase, Chinese Web of Knowledge, Wanfang, and Chongqing VIP database. The database was searched up to December 2016 and includes language of English and/or Chinese with the keywords of "obsessive-compulsive disorder" or "OCD," polymorphism or variant or mutation, "tumor necrosis factor" or "TNF" or "cytokine." The association between TNF-?-238G/A gene polymorphism and the susceptibility of OCD was anticipated by odds ratio (OR) with the corresponding 95% confidence interval (95% CI).Four studies including 435 cases and 1073 controls were incorporated in our meta-analysis. In general, TNF-?-238G/A gene polymorphism might lead to a decreased risk of OCD susceptibility (G vs A genotype model: OR?=?1.01, 95% CI?=?0.37-2.77, P?=?.981; GG vs AA+AG model: OR?=?0.93, 95% CI?=?0.37-2.36, P?=?.879; GG+AG vs AA model: OR?=?0.22, 95% CI?=?0.06-0.73, P?=?.014; GG vs AA model: OR?=?0.21, 95% CI?=?0.06-0.71, P?=?.012; AG vs AA model: OR?=?0.29, 95% CI?=?0.07-1.16, P?=?.081; GG+AA vs AG model: OR?=?1.17, 95% CI?=?0.55-2.51, P?=?.683).TNF-?-238G/A gene polymorphism might lead to a decreased risk of OCD susceptibility.

SUBMITTER: Jiang C

PROVIDER: S-EPMC5805438 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Association between TNF-α-238G/A gene polymorphism and OCD susceptibility: A meta-analysis.

Jiang Caixiao C Ma Xinyan X Qi Shunxiang S Han Guangyue G Li Yan Y Liu Yanfang Y Liu Lanfen L

Medicine 20180201 5

<h4>Background</h4>Tumor necrosis factor-alpha (TNF-α) is an important cytokine and has been reported to be associated with the pathogenesis of many autoimmune and inflammatory diseases. TNF-α gene is located on a region that has been found to be associated with obsessive-compulsive disorder (OCD). We performed this meta-analysis to assess the relationship between susceptibility to OCD and the TNF-α-238G/A gene polymorphism.<h4>Methods</h4>An extensive search of the available literature on the a ...[more]

PMID: 29384866

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Project description:To investigate the association between the susceptibility to cervical cancer and the single nucleotide polymorphisms of 5 tumor necrosis factor-α promoter genes (rs361525, rs1800629, rs1800750, rs1799964, and rs673) in Chinese women. A total of 946 peripheral blood samples were collected from women of Han Ethnicity in Shandong province. Of them, 452 were diagnosed with cervical squamous cell carcinomas. The study also included a control group of 494 healthy women. The targeted single nucleotide polymorphisms were analyzed by TaqMan probe method. (1) The rate of high-risk subtype human papillomavirus infection in exfoliated cervical epithelial cells was significantly higher in patients with cervical cancer than the control group (91.4% vs 10.3%, P < .01). The rate of human papillomavirus infection was lower in patients with carcinoma in situ than those with invasive carcinoma (77.9% vs 95.4%, P < .01). (2) There was a significant difference for rs361525 genotype (CC/CT/TT) between the control, carcinoma in situ, and invasive carcinoma groups ( P < .001). Both rs1800629 and rs1799964 genotypes (both GG/GA/AA) were also different between these groups ( P < .001 and P < .001). (3) The allele frequencies of rs361525, rs1800629, and rs1799964 were significantly correlated with the diagnosis of cervical cancer. The frequency of T allele in rs361525 was significantly higher for cervical cancer group (10.8%) than control group (3.8%; odds ratio = 3.04, 95% confidence interval = 1.76-5.25, P < .01). The frequency of A allele in rs1800629 was significantly higher for cervical cancer (29.9%) than control group (14.2%; odds ratio = 2.58, 95% confidence interval = 1.87-3.56, P < .01). The frequency of A allele in rs1799964 was also higher for cervical cancer group (38.3%) than control group (16.4%; odds ratio = 1.43, 95% confidence interval = 1.07-1.91, P < .05). The rs361525, rs1800629, and rs17999645 were significantly correlated with the diagnosis of cervical cancer.

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Dataset Information

Association between TNF-?-238G/A gene polymorphism and OCD susceptibility: A meta-analysis.

Publications

Association between TNF-α-238G/A gene polymorphism and OCD susceptibility: A meta-analysis.

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