The TNF-alpha-238 polymorphism and cancer risk: a meta-analysis.

ABSTRACT: BACKGROUND AND OBJECTIVES: Tumor necrosis factor-? (TNF-?) plays a very important role in the development and progress of cancer. Some TNF-? polymorphisms have been confirmed to increase cancer risks; however, the association between TNF-?-238 polymorphism and cancers remains controversial and ambiguous. The aim of this study is to explore a more precise estimation of its relationship with cancer using meta-analysis. METHODS: Electronic searches of several databases were conducted for all publications on the association between this variant and cancer through March 2011. Odds ratios (OR) with 95% confidence intervals (95% CI) were used to access the strength of this association in the random-effect model. RESULTS: Thirty four studies with 34,679 cancer patients and 41,186 healthy controls were included. This meta-analysis showed no significant association between TNF-?-238 polymorphism and cancers (AA+GA vs GG: OR?=?1.09, 95%CI?=?0.88-1.34). In Caucasian and Asian subgroups, OR values (95% CI) were 1.14 (0.91-1.43) and 0.97 (0.58-1.61), respectively. In the subgroups of cancer type, no significant association was detected. The sensitivity analysis further strengthened the validity of these negative associations. No publication bias was observed in this study. CONCLUSIONS: No significant association was found between the TNF-?-238 polymorphism and the risk for cancer.

SUBMITTER: Zhou P 

PROVIDER: S-EPMC3139602 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature