Ontology highlight
ABSTRACT:
SUBMITTER: Feng J
PROVIDER: S-EPMC5661746 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Nature communications 20171030 1
Although both persistent itch and inflammation are commonly associated with allergic contact dermatitis (ACD), it is not known if they are mediated by shared or distinct signaling pathways. Here we show that both TRPA1 and TRPV1 channels are required for generating spontaneous scratching in a mouse model of ACD induced by squaric acid dibutylester (SADBE), a small molecule hapten, through directly promoting the excitability of pruriceptors. TRPV1 but not TRPA1 channels protect the skin inflammat ...[more]