TRP Channels as Drug Targets to Relieve Itch.
Ontology highlight
ABSTRACT:
SUBMITTER: Xie Z
PROVIDER: S-EPMC6316386 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
TRP Channels as Drug Targets to Relieve Itch.
Pharmaceuticals (Basel, Switzerland) 20181006 4
Although acute itch has a protective role by removing irritants to avoid further damage, chronic itch is debilitating, significantly impacting quality of life. Over the past two decades, a considerable amount of stimulating research has been carried out to delineate mechanisms of itch at the molecular, cellular, and circuit levels. There is growing evidence that transient receptor potential (TRP) channels play important roles in itch signaling. The purpose of this review is to summarize our curr ...[more]
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