Therapeutic implications of bioactive sphingolipids: A focus on colorectal cancer.
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ABSTRACT:
SUBMITTER: Camp ER
PROVIDER: S-EPMC5663409 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Therapeutic implications of bioactive sphingolipids: A focus on colorectal cancer.
Camp E Ramsay ER Patterson Logan D LD Kester Mark M Voelkel-Johnson Christina C
Cancer biology & therapy 20170707 9
Therapy of colorectal cancer (CRC), especially a subset known as locally advanced rectal cancer, is challenged by progression and recurrence. Sphingolipids, a lipid subtype with vital roles in cellular function, play an important role in CRC and impact on therapeutic outcomes. In this review we discuss how dietary sphingolipids or the gut microbiome via alterations in sphingolipids influence CRC carcinogenesis. In addition, we discuss the expression of sphingolipid enzymes in the gastro-intestin ...[more]
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