Ontology highlight
ABSTRACT:
SUBMITTER: Ho CC
PROVIDER: S-EPMC5664135 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Ho Chi-Chun CC Fong Wai-Ying WY Lee Yuen-Hon YH Poon Wing-Tat WT
Genes 20171023 10
Thiopurines are clinically useful in the management of diverse immunological and malignant conditions. Nevertheless, these purine analogues can cause lethal myelosuppression, which may be prevented by prospective testing for variants in the thiopurine S-methyltransferase (<i>TPMT</i>) and, in East Asians, Nudix hydrolase 15 (<i>NUDT15</i>) genes. Two single-tube, tetra-primer amplification refractory mutation system polymerase chain reaction (ARMS-PCR) assays were developed to genotype the commo ...[more]