Ontology highlight
ABSTRACT:
SUBMITTER: Jia J
PROVIDER: S-EPMC5667415 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Jia Jiantao J Shi Ying Y Chen Ling L Lai Weiwei W Yan Bin B Jiang Yiqun Y Xiao Desheng D Xi Sichuan S Cao Ya Y Liu Shuang S Cheng Yan Y Tao Yongguang Y
Theranostics 20170905 16
DNA methylation is an important epigenetic modification as a hallmark in cancer. Conversion of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) by ten-eleven translocation (TET) family enzymes plays an important biological role in embryonic stem cells, development, aging and disease. Lymphoid specific helicase (LSH), a chromatin remodeling factor, is regarded as a reader of 5-hmC. Recent reports show that the level of 5-hmC is altered in various types of cancers. However, the change in ...[more]