Ontology highlight
ABSTRACT:
SUBMITTER: Mischo HE
PROVIDER: S-EPMC3314950 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Mischo Hannah E HE Gómez-González Belén B Grzechnik Pawel P Rondón Ana G AG Wei Wu W Steinmetz Lars L Aguilera Andrés A Proudfoot Nick J NJ
Molecular cell 20110101 1
Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription termination of nonpolyadenylated as well as some polyadenylated RNA polymerase II transcripts. We now show that Sen1 helicase possesses a wider function by restricting the occurrence of RNA:DNA hybrids that may naturally form during transcription, when nascent RNA hybridizes to DNA prior to its packaging into RNA protein complexes. These hybrids displace the nontranscribed strand and create R loop structure ...[more]