Epigenome-wide association studies identify DNA methylation associated with kidney function.
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ABSTRACT:
SUBMITTER: Chu AY
PROVIDER: S-EPMC5668367 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
Epigenome-wide association studies identify DNA methylation associated with kidney function.
Chu Audrey Y AY Tin Adrienne A Schlosser Pascal P Ko Yi-An YA Qiu Chengxiang C Yao Chen C Joehanes Roby R Grams Morgan E ME Liang Liming L Gluck Caroline A CA Liu Chunyu C Coresh Josef J Hwang Shih-Jen SJ Levy Daniel D Boerwinkle Eric E Pankow James S JS Yang Qiong Q Fornage Myriam M Fox Caroline S CS Susztak Katalin K Köttgen Anna A
Nature communications 20171103 1
Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham Heart Study participants to identify epigenetic signatures of kidney function. Of 19 CpG sites significantly associated (P < 1e-07) with eGFR/CKD and replicated, five also associat ...[more]
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