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DNA methylation signatures of incident coronary heart disease: findings from epigenome-wide association studies.


ABSTRACT: Coronary heart disease (CHD) is a type of cardiovascular disease (CVD) that affects the coronary arteries, which provide oxygenated blood to the heart. It is a major cause of mortality worldwide. Various prediction methods have been developed to assess the likelihood of developing CHD, including those based on clinical features and genetic variation. Recent epigenome-wide studies have identified DNA methylation signatures associated with the development of CHD, indicating that DNA methylation may play a role in predicting future CHD. This narrative review summarises recent findings from DNA methylation studies of incident CHD (iCHD) events from epigenome-wide association studies (EWASs). The results suggest that DNA methylation signatures may identify new mechanisms involved in CHD progression and could prove a useful adjunct for the prediction of future CHD.

SUBMITTER: Xia Y 

PROVIDER: S-EPMC8501606 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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DNA methylation signatures of incident coronary heart disease: findings from epigenome-wide association studies.

Xia Yujing Y   Brewer Alison A   Bell Jordana T JT  

Clinical epigenetics 20211009 1


Coronary heart disease (CHD) is a type of cardiovascular disease (CVD) that affects the coronary arteries, which provide oxygenated blood to the heart. It is a major cause of mortality worldwide. Various prediction methods have been developed to assess the likelihood of developing CHD, including those based on clinical features and genetic variation. Recent epigenome-wide studies have identified DNA methylation signatures associated with the development of CHD, indicating that DNA methylation ma  ...[more]

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