Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC5669015 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Microbial cell factories 20171102 1
<h4>Background</h4>Malonyl-coenzyme A (CoA) is an important biosynthetic precursor in vivo. Although Escherichia coli is a useful organism for biosynthetic applications, its malonyl-CoA level is too low.<h4>Results</h4>To identify strains with the best potential for enhanced malonyl-CoA production, we developed a whole-cell biosensor for rapidly reporting intracellular malonyl-CoA concentrations. The biosensor was successfully applied as a high-throughput screening tool for identifying targets a ...[more]