Ontology highlight
ABSTRACT:
SUBMITTER: Fu FF
PROVIDER: S-EPMC5672071 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Fu Fen-Fen FF Zhu Xiao-Jian XJ Wang Hong-Xiang HX Zhang Li-Ming LM Yuan Guo-Lin GL Chen Zhi-Chao ZC Li Qiu-Bai QB
Acta pharmacologica Sinica 20170824 11
The intercellular communication between leukemia cells and bone marrow mesenchymal stem cells (BM-MSCs) plays more important role in chronic myeloid leukemia (CML) than we previously understood. Recently, we found that microvesicles released from human leukemia cell line K562 (K562-MVs) containing BCR-ABL1 mRNA malignantly transformed normal hematopoietic transplants. Here, we investigated whether K562-MVs contribute to the transformation of human bone marrow mesenchymal stem cells (BM-MSCs). We ...[more]