Ontology highlight
ABSTRACT:
SUBMITTER: Kanaan GN
PROVIDER: S-EPMC5675898 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Kanaan Georges N GN Ichim Bianca B Gharibeh Lara L Maharsy Wael W Patten David A DA Xuan Jian Ying JY Reunov Arkadiy A Marshall Philip P Veinot John J Menzies Keir K Nemer Mona M Harper Mary-Ellen ME
Redox biology 20171026
Glutaredoxin 2 (GRX2), a mitochondrial glutathione-dependent oxidoreductase, is central to glutathione homeostasis and mitochondrial redox, which is crucial in highly metabolic tissues like the heart. Previous research showed that absence of Grx2, leads to impaired mitochondrial complex I function, hypertension and cardiac hypertrophy in mice but the impact on mitochondrial structure and function in intact cardiomyocytes and in humans has not been explored. We hypothesized that Grx2 controls car ...[more]