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Polymorphisms in CCR5?32 and Risk of HIV-1 Infection in the Southeast of Caspian Sea, Iran.


ABSTRACT: Prevalence of CCR5?32 among blood samples of more than 400 healthy and HIV-1-infected people was investigated in Iran. Polymerase chain reaction (PCR) following DNA extraction was used. Desired frequency was analyzed by Hardy-Weinberg equilibrium (HWE) analysis and SPSS 16.0 software to harvest the results. The prevalence of CCR?32 heterozygote genotype was 3% in healthy people and 0.7% in HIV-1-infected individuals. There was no homozygote CCR5?32 in both groups, and the allele ?32 was only observed in 1.5% and 0.36% of healthy and HIV-1-infected participants, respectively. Therefore according to this study, the frequency of the allele CCR5?32 indicates no significant difference between either groups (p = 0.18) and it sounds that the mentioned mutation in heterozygote people would not affect their susceptibility against HIV infection. Genotyping trial in Iranians with HIV infection is supposed to be helpful as a matter of prognostic purposes.

SUBMITTER: Heydarifard Z 

PROVIDER: S-EPMC5676439 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Polymorphisms in CCR5Δ32 and Risk of HIV-1 Infection in the Southeast of Caspian Sea, Iran.

Heydarifard Zahra Z   Tabarraei Alijan A   Moradi Abdolvahab A  

Disease markers 20171025


Prevalence of CCR5Δ32 among blood samples of more than 400 healthy and HIV-1-infected people was investigated in Iran. Polymerase chain reaction (PCR) following DNA extraction was used. Desired frequency was analyzed by Hardy-Weinberg equilibrium (HWE) analysis and SPSS 16.0 software to harvest the results. The prevalence of CCRΔ32 heterozygote genotype was 3% in healthy people and 0.7% in HIV-1-infected individuals. There was no homozygote CCR5Δ32 in both groups, and the allele Δ32 was only obs  ...[more]

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