Ron receptor overexpression in the murine prostate induces prostate intraepithelial neoplasia.
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ABSTRACT:
SUBMITTER: Gray JK
PROVIDER: S-EPMC3225593 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Ron receptor overexpression in the murine prostate induces prostate intraepithelial neoplasia.
Gray Jerilyn K JK Paluch Andrew M AM Stuart William D WD Waltz Susan E SE
Cancer letters 20110924 1
Previous studies have shown that the Ron receptor is overexpressed in prostate cancer and Ron expression increases with disease severity in humans and the mouse TRAMP model. Here, the causal role of Ron overexpression in the murine prostate was examined in the development and progression of prostate cancer. Transgenic mouse strains were generated which selectively overexpressed Ron in the prostate epithelium and prostate histopathology was evaluated and compared to wild type controls. Ron overex ...[more]
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