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HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections.


ABSTRACT: Transcriptional regulation of numerous interferon-regulated genes, including Toll-like receptor 3 (Tlr3), which encodes an innate immune sensor of viral double-stranded RNA, depends on the interferon regulatory factor 1 (IRF1) and IRF2 transcription factors. We detected specific abrogation of macrophage responses to polyinosinic-polycytidylic acid (poly(I:C)) resulting from three independent N-ethyl-N-nitrosourea-induced mutations in host cell factor C2 (Hcfc2). Hcfc2 mutations compromised survival during influenza virus and herpes simplex virus 1 infections. HCFC2 promoted the binding of IRF1 and IRF2 to the Tlr3 promoter, without which inflammatory cytokine and type I IFN responses to the double-stranded RNA analogue poly(I:C) are reduced in mouse macrophages. HCFC2 was also necessary for the transcription of a large subset of other IRF2-dependent interferon-regulated genes. Deleterious mutations of Hcfc2 may therefore increase susceptibility to diverse infectious diseases.

SUBMITTER: Sun L 

PROVIDER: S-EPMC5679162 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Transcriptional regulation of numerous interferon-regulated genes, including <i>Toll-like receptor 3</i> (<i>Tlr3</i>), which encodes an innate immune sensor of viral double-stranded RNA, depends on the interferon regulatory factor 1 (IRF1) and IRF2 transcription factors. We detected specific abrogation of macrophage responses to polyinosinic-polycytidylic acid (poly(I:C)) resulting from three independent <i>N</i>-ethyl-<i>N</i>-nitrosourea-induced mutations in <i>host cell factor C2</i> (<i>Hcf  ...[more]

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