Ontology highlight
ABSTRACT:
SUBMITTER: Shin Y
PROVIDER: S-EPMC6794630 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Shin Yoojin Y Choi Se Hoon SH Kim Eunhee E Bylykbashi Enjana E Kim Jeong Ah JA Chung Seok S Kim Doo Yeon DY Kamm Roger D RD Tanzi Rudolph E RE
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20190812 20
Harmful materials in the blood are prevented from entering the healthy brain by a highly selective blood-brain barrier (BBB), and impairment of barrier function has been associated with a variety of neurological diseases. In Alzheimer's disease (AD), BBB breakdown has been shown to occur even before cognitive decline and brain pathology. To investigate the role of the cerebral vasculature in AD, a physiologically relevant 3D human neural cell culture microfluidic model is developed having a brai ...[more]