Ontology highlight
ABSTRACT:
SUBMITTER: LaMere SA
PROVIDER: S-EPMC5679303 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
LaMere Sarah A SA Thompson Ryan C RC Meng Xiangzhi X Komori H Kiyomi HK Mark Adam A Salomon Daniel R DR
Journal of immunology (Baltimore, Md. : 1950) 20170925 9
The changes to the epigenetic landscape in response to Ag during CD4 T cell activation have not been well characterized. Although CD4 T cell subsets have been mapped globally for numerous epigenetic marks, little has been done to study their dynamics early after activation. We have studied changes to promoter H3K27me3 during activation of human naive and memory CD4 T cells. Our results show that these changes occur relatively early (1 d) after activation of naive and memory cells and that demeth ...[more]