Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez E
PROVIDER: S-EPMC5679314 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Fernandez Estefania E Dejnirattisai Wanwisa W Cao Bin B Scheaffer Suzanne M SM Supasa Piyada P Wongwiwat Wiyada W Esakky Prabagaran P Drury Andrea A Mongkolsapaya Juthathip J Moley Kelle H KH Mysorekar Indira U IU Screaton Gavin R GR Diamond Michael S MS
Nature immunology 20170925 11
The Zika virus (ZIKV) epidemic has resulted in congenital abnormalities in fetuses and neonates. Although some cross-reactive dengue virus (DENV)-specific antibodies can enhance ZIKV infection in mice, those recognizing the DENV E-dimer epitope (EDE) can neutralize ZIKV infection in cell culture. We evaluated the therapeutic activity of human monoclonal antibodies to DENV EDE for their ability to control ZIKV infection in the brains, testes, placentas, and fetuses of mice. A single dose of the E ...[more]