Ontology highlight
ABSTRACT:
SUBMITTER: Remmel JL
PROVIDER: S-EPMC8205970 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Remmel Jennifer L JL Frei Julia C JC Butler Savannah E SE Lai Jonathan R JR Ackerman Margaret E ME
Virology 20210330
Antibodies (Abs) recognizing the Dengue virus (DENV) E dimer epitope (EDE) that potently neutralize all DENV serotypes are promising templates for vaccine design. As an important feature for some Abs is their bivalency, we sought to define the role avidity plays in neutralization by EDE Abs. We compared neutralization activity between bivalent IgGs and monovalent Ab fragments (Fabs) for two EDE Abs, A11 and C10. IgG forms of both Abs exhibited more potent neutralization activity than their count ...[more]