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New chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents.

ABSTRACT: The synthesis of 3-[3/4-(2-aryl-2-oxoethoxy)arylidene]chroman/thiochroman-4-one derivatives (1-34) and evaluation of their anticancer activities were aimed in this work. Final compounds were obtained in multistep synthesis reactions using phenol/thiophenol derivatives as starting materials. For anticancer activity evaluation, all compounds were offered to National Cancer Institute (NCI), USA and selected ones were tested against sixty human tumor cell lines derived from nine neoplastic diseases. The activity results were evaluated according to the drug screening protocol of the institute. Compounds containing thiochromanone skeleton exhibited higher anticancer activity.

SUBMITTER: Demirayak S

PROVIDER: S-EPMC5681300 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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New chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents.

Demirayak Seref S Yurttas Leyla L Gundogdu-Karaburun Nalan N Karaburun Ahmet Cagri AC Kayagil Ismail I

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society 20170426 7

The synthesis of 3-[3/4-(2-aryl-2-oxoethoxy)arylidene]chroman/thiochroman-4-one derivatives (1-34) and evaluation of their anticancer activities were aimed in this work. Final compounds were obtained in multistep synthesis reactions using phenol/thiophenol derivatives as starting materials. For anticancer activity evaluation, all compounds were offered to National Cancer Institute (NCI), USA and selected ones were tested against sixty human tumor cell lines derived from nine neopla ...[more]

PMID: 29158716

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