Ontology highlight
ABSTRACT:
SUBMITTER: Xu W
PROVIDER: S-EPMC6155299 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Xu Weijie W Pan Ying Y Wang Hong H Li Haiyan H Peng Qing Q Wei Duncan D Chen Cheng C Zheng Jinhong J
Molecules (Basel, Switzerland) 20170316 3
Cancer is a major public health concern worldwide. Adverse effects of cancer treatments still compromise patients' quality of life. To identify new potential anticancer agents, a series of novel pyrazoline derivatives were synthesized and evaluated for cytotoxic effects on HepG-2 (human liver hepatocellular carcinoma cell line) and primary hepatocytes. Compound structures were confirmed by ¹H-NMR, mass spectrometry, and infrared imaging. An in vitro assay demonstrated that several compounds exer ...[more]