Manzamine A as a novel inhibitor of herpes simplex virus type-1 replication in cultured corneal cells.
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ABSTRACT:
SUBMITTER: Palem JR
PROVIDER: S-EPMC5682632 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
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Manzamine A as a novel inhibitor of herpes simplex virus type-1 replication in cultured corneal cells.
Palem Jayavardhana R JR Bedadala Gautam R GR El Sayed Khalid A KA Hsia Shao-chung V SC
Planta medica 20100719 1
This study investigated the putative inhibitory effect of manzamine A on HSV-1 infection. Our results indicated that manzamine A effectively inhibited viral replication and infection in the cell line SIRC, a corneal cell line, at 1 µM. The existing anti-HSV-1 drug acyclovir was analyzed and showed a comparable activity at 50 µM. Plaque assays demonstrated that manzamine A reduced the release of infectious virus by 10 (11)-fold. RTPCR assays indicated that HSV-1 virion host shutoff (vhs) activity ...[more]
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