Ontology highlight
ABSTRACT:
SUBMITTER: Gopaldass N
PROVIDER: S-EPMC5686546 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
The EMBO journal 20171013 22
Sorting, transport, and autophagic degradation of proteins in endosomes and lysosomes, as well as the division of these organelles, depend on scission of membrane-bound tubulo-vesicular carriers. How scission occurs is poorly understood, but family proteins bind these membranes. Here, we show that the yeast PROPPIN Atg18 carries membrane scission activity. Purified Atg18 drives tubulation and scission of giant unilamellar vesicles. Upon membrane contact, Atg18 folds its unstructured CD loop into ...[more]