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Amatuximab and novel agents targeting mesothelin for solid tumors.

ABSTRACT: Mesothelin (MSLN) is considered a promising target for cancer therapy. Originally extracted in 1992 after the immunization of mice with a human ovarian cancer (OC) cell line and cloned in 1996, MSLN seems to be involved in cell adhesion and metastasis. MSLN is prevalent in mesothelia tissues but is expressed in several human cancers, such as OC, pancreatic cancer, mesothelioma, and lung cancer. Amatuximab (MORAb-009) is a mouse-human chimeric monoclonal antibody with a selective affinity for MSLN. The principal mechanism of action comprises inhibition of binding of MSLN with the antigen CA125/MUC16. The highest phase of development is actually a Phase II trial (MORAb-009-201, Europe). In this review, we describe the mechanism of action of amatuximab and other MSLN-targeting novel drugs, along with a discussion about the expected efficacy, safety, and toxicity of this promising group of agents and implications for future research and clinical practice.

SUBMITTER: Baldo P

PROVIDER: S-EPMC5687483 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Amatuximab and novel agents targeting mesothelin for solid tumors.

Baldo Paolo P Cecco Sara S

OncoTargets and therapy 20171108

Mesothelin (MSLN) is considered a promising target for cancer therapy. Originally extracted in 1992 after the immunization of mice with a human ovarian cancer (OC) cell line and cloned in 1996, MSLN seems to be involved in cell adhesion and metastasis. MSLN is prevalent in mesothelia tissues but is expressed in several human cancers, such as OC, pancreatic cancer, mesothelioma, and lung cancer. Amatuximab (MORAb-009) is a mouse-human chimeric monoclonal antibody with a selective affinity for MSL ...[more]

PMID: 29184420

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Novel Antibody Therapeutics Targeting Mesothelin In Solid Tumors.

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| S-EPMC5080863 | biostudies-literature

Phase I study of amatuximab, a novel monoclonal antibody to mesothelin, in Japanese patients with advanced solid tumors.

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| S-EPMC4387254 | biostudies-literature

A Novel T Cell-Engaging Bispecific Antibody for Treating Mesothelin-Positive Solid Tumors.

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| S-EPMC7175222 | biostudies-literature

Mesothelin-Targeted CARs: Driving T Cells to Solid Tumors.

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| S-EPMC4744527 | biostudies-literature

Mesothelin-targeted CAR-T cells for adoptive cell therapy of solid tumors.

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| S-EPMC8425252 | biostudies-literature

Mesothelin blockage by Amatuximab suppresses cell invasiveness, enhances gemcitabine sensitivity and regulates cancer cell stemness in mesothelin-positive pancreatic cancer cells.

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| S-EPMC7912898 | biostudies-literature

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