Ontology highlight
ABSTRACT:
SUBMITTER: Teng P
PROVIDER: S-EPMC5690803 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Teng Peng P Nimmagadda Alekhya A Su Ma M Hong Yuzhu Y Shen Ning N Li Chunpu C Tsai Ling-Yu LY Cao Jessica J Li Qi Q Cai Jianfeng J
Chemical communications (Cambridge, England) 20171001 87
We designed a class of small dimeric cyclic guanidine derivatives which display potent antibacterial activity against both multidrug-resistant Gram-negative and Gram-positive bacteria. They could compromise bacterial membranes without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in the MRSA-infected thigh burden mouse model. ...[more]