Ontology highlight
ABSTRACT:
SUBMITTER: Sze A
PROVIDER: S-EPMC5691638 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Sze Alexandre A Olagnier David D Hadj Samar Bel SB Han Xiaoying X Tian Xiao Hong XH Xu Hong-Tao HT Yang Long L Shi Qingwen Q Wang Penghua P Wainberg Mark A MA Wu Jian Hui JH Lin Rongtuan R
Viruses 20171003 10
Flaviviruses including Zika, Dengue and Hepatitis C virus cause debilitating diseases in humans, and the former are emerging as global health concerns with no antiviral treatments. We investigated <i>Sophora Flavecens</i>, used in Chinese medicine, as a source for antiviral compounds. We isolated Sophoraflavenone G and found that it inhibited Hepatitis C replication, but not Sendai or Vesicular Stomatitis Virus. Pre- and post-infection treatments demonstrated anti-flaviviral activity against Den ...[more]