Ontology highlight
ABSTRACT:
SUBMITTER: Das PK
PROVIDER: S-EPMC5694895 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Das Pradipta K PK Dean Dexter N DN Fogel April L AL Liu Fei F Abel Brooks A BA McCormick Charles L CL Kharlampieva Eugenia E Rangachari Vijayaraghavan V Morgan Sarah E SE
Biomacromolecules 20170926 10
GM1 ganglioside is known to promote amyloid-β (Aβ) peptide aggregation in Alzheimer's disease. The roles of the individual saccharides and their distribution in this process are not understood. Acrylamide-based glycomonomers with either β-d-glucose or β-d-galactose pendant groups were synthesized to mimic the stereochemistry of saccharides present in GM1 and characterized via <sup>1</sup>H NMR and electrospray ionization mass spectrometry. Glycopolymers of different molecular weights were synthe ...[more]