Dataset Information

Clinical prediction rule for neurological sequelae due to acute encephalopathy: a medical community-based validation study in Harima, Japan.

ABSTRACT:

Objectives

This study aimed to verify the screening performance of our clinical prediction rule for neurological sequelae due to acute encephalopathy (NSAE-CPR), which previously identified the following three variables as predictive of poor outcomes: (1) refractory status epilepticus; (2) consciousness disturbance and/or hemiplegia at 6 hours from onset and (3) aspartate aminotransferase >90 IU/L within 6 hours of onset.

Design

Medical community-based multicentre retrospective cohort study.

Setting

Six regional hospitals in Harima and one tertiary centre in Kobe, Japan, from 2008 to 2012.

Participants

We enrolled a total of 1612 patients aged <16 years who met the diagnostic criteria for an initial diagnosis of complex febrile seizure. Patients with a history of neurological disease and those included in the derivation cohort were excluded.

Primary outcome measures

Univariate and multivariate analyses were performed to determine the association between each of the three predictor variables and poor AE outcome (Pediatric Cerebral Performance Category score ?2). Receiver operating characteristic curve (ROC) analysis was also performed to assess the screening performance of the NSAE-CPR.

Results

The ROC analysis identified at least one of the three predictive variables as an optimal cut-off point, with an area under the curve of 0.915 (95% CI 0.825 to 1.000). The sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios and Matthews correlation coefficient were 0.867, 0.954, 0.149, 0.999, 18.704, 0.140 and 0.349, respectively.

Conclusions

Our findings indicate that the NSAE-CPR can be used for the screening and identification of patients with poor outcomes due to acute encephalopathy within 6 hours of onset.

SUBMITTER: Sasaki K

PROVIDER: S-EPMC5695471 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Publications

Clinical prediction rule for neurological sequelae due to acute encephalopathy: a medical community-based validation study in Harima, Japan.

Sasaki Kaori K Nagase Hiroaki H Maruyama Azusa A Fujita Kyoko K Nishiyama Masahiro M Tanaka Tsukasa T Nukina Sadayuki S Takumi Toru T Takenaka Kanae K Oyazato Yoshinobu Y Nishiyama Atsushi A Kawata Tomoko T Saeki Keisuke K Takami Yuichi Y Satake-Inoue Eriko E Iijima Kazumoto K Morioka Ichiro I Uetani Yoshiyuki Y

BMJ open 20171109 11

<h4>Objectives</h4>This study aimed to verify the screening performance of our clinical prediction rule for neurological sequelae due to acute encephalopathy (NSAE-CPR), which previously identified the following three variables as predictive of poor outcomes: (1) refractory status epilepticus; (2) consciousness disturbance and/or hemiplegia at 6 hours from onset and (3) aspartate aminotransferase >90 IU/L within 6 hours of onset.<h4>Design</h4>Medical community-based multicentre retrospective co ...[more]

PMID: 29127224

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Dataset Information

Clinical prediction rule for neurological sequelae due to acute encephalopathy: a medical community-based validation study in Harima, Japan.

Objectives

Design

Setting

Participants

Primary outcome measures

Results

Conclusions

Publications

Clinical prediction rule for neurological sequelae due to acute encephalopathy: a medical community-based validation study in Harima, Japan.

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