Ontology highlight
ABSTRACT:
SUBMITTER: Lao-Peregrin C
PROVIDER: S-EPMC5697621 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Lao-Peregrín Cristina C Ballesteros Jesús Javier JJ Fernández Miriam M Zamora-Moratalla Alfonsa A Saavedra Ana A Gómez Lázaro María M Pérez-Navarro Esther E Burks Deborah D Martín Eduardo D ED
Addiction biology 20160725 6
Caffeine has cognitive-enhancing properties with effects on learning and memory, concentration, arousal and mood. These effects imply changes at circuital and synaptic level, but the mechanism by which caffeine modifies synaptic plasticity remains elusive. Here we report that caffeine, at concentrations representing moderate to high levels of consumption in humans, induces an NMDA receptor-independent form of LTP (<sub>CAF</sub> LTP) in the CA1 region of the hippocampus by promoting calcium-depe ...[more]