Ontology highlight
ABSTRACT:
SUBMITTER: Nie H
PROVIDER: S-EPMC5699232 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Journal of cell signaling 20170912 3
The SET and <i>Mynd</i> domain 1 (<i>Smyd1</i>) locus encodes three tissue-restricted isoforms. Two previously characterized isoforms, <i>Smyd1A</i> and <i>Smyd1B</i><b>,</b> are heart and skeletal muscle-restricted histone methyl transferases. Here we report that a third, non-catalytic isoform, <i>Smyd1C</i><b>,</b> is expressed predominantly in activated CD8 T cells. While <i>Smyd1C</i><b>-</b> deficient CD8 T cells undergo activation-induced apoptosis, neither of two classical mechanisms acti ...[more]