Ontology highlight
ABSTRACT:
SUBMITTER: Rashid M
PROVIDER: S-EPMC5702069 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Rashid Mamunur M Belmont Judson J Carpenter David D Turner Christopher E CE Olson Eric C EC
Development (Cambridge, England) 20170921 21
Paxillin and Hic-5 are homologous focal adhesion adaptor proteins that coordinate cytoskeletal rearrangements in response to integrin signaling, but their role(s) in cortical development are unknown. Here, we find that Hic-5-deficient mice are postnatal viable with normal cortical layering. Mice with a neural-specific deletion of paxillin are also postnatal viable, but show evidence of a cortical neuron migration delay that is evident pre- and perinatally, but is not detected at postnatal day 35 ...[more]