Ontology highlight
ABSTRACT:
SUBMITTER: Moreno-Fortuny A
PROVIDER: S-EPMC5703611 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Moreno-Fortuny Artal A Bragg Laricia L Cossu Giulio G Roostalu Urmas U
Biology open 20171115 11
Cell polarity has a fundamental role in shaping the morphology of cells and growing tissues. Polarity is commonly thought to be established in response to extracellular signals. Here we used a minimal <i>in vitro</i> assay that enabled us to monitor the determination of cell polarity in myogenic and chondrogenic differentiation in the absence of external signalling gradients. We demonstrate that the initiation of cell polarity is regulated by melanoma cell adhesion molecule (MCAM). We found high ...[more]