Ontology highlight
ABSTRACT:
SUBMITTER: Wyant GA
PROVIDER: S-EPMC5704964 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Wyant Gregory A GA Abu-Remaileh Monther M Wolfson Rachel L RL Chen Walter W WW Freinkman Elizaveta E Danai Laura V LV Vander Heiden Matthew G MG Sabatini David M DM
Cell 20171001 3
The mTORC1 kinase is a master growth regulator that senses many environmental cues, including amino acids. Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters. Here, we validate that SLC38A9 is an arginine sensor for the mTORC1 pathway, and we uncover an unexpectedly central role for SLC38A9 in amino acid homeostasis. SLC38A9 mediates the transport, in an arginine-regulated fashion, of many essential amino aci ...[more]