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Methylthio-aspochalasins from a marine-derived fungus Aspergillus sp.

ABSTRACT: Two novel aspochalasins, 20-β-methylthio-aspochalsin Q (named as aspochalasin V), (1) and aspochalasin W (2), were isolated from culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. The structures were determined on the basis of NMR and mass spectral data analysis. This is the first report about methylthio-substituted aspochalasin derivatives. Cytotoxicity against the prostate cancer PC3 cell line and HCT116 cell line was assayed using the MTT method. Apochalasin V showed moderate activity at IC50 values of 30.4 and 39.2 μM, respectively.

SUBMITTER: Liu Y

PROVIDER: S-EPMC4210888 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Methylthio-aspochalasins from a marine-derived fungus Aspergillus sp.

Liu Ying Y Zhao Shizhe S Ding Wanjing W Wang Pinmei P Yang Xianwen X Xu Jinzhong J

Marine drugs 20140930 10

Two novel aspochalasins, 20-β-methylthio-aspochalsin Q (named as aspochalasin V), (1) and aspochalasin W (2), were isolated from culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. The structures were determined on the basis of NMR and mass spectral data analysis. This is the first report about methylthio-substituted aspochalasin derivatives. Cytotoxicity against the prostate cancer PC3 cell line and HCT116 cell line was assayed using the MTT method. A ...[more]

PMID: 25272329

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