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Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex.

ABSTRACT: Proteins typically carry out their biological functions as multi-protein complexes, which can significantly affect the affinity of small-molecule inhibitors. HSP70 is an important target in oncology, so to study its chemical biology and the drug discovery potential of the HSP70/BAG1 complex, we designed a high-affinity non-nucleotide fluorescence polarisation probe.

SUBMITTER: Evans LE

PROVIDER: S-EPMC5708526 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex.

Evans Lindsay E LE Jones Keith K Cheeseman Matthew D MD

Chemical communications (Cambridge, England) 20170501 37

Proteins typically carry out their biological functions as multi-protein complexes, which can significantly affect the affinity of small-molecule inhibitors. HSP70 is an important target in oncology, so to study its chemical biology and the drug discovery potential of the HSP70/BAG1 complex, we designed a high-affinity non-nucleotide fluorescence polarisation probe. ...[more]

PMID: 28439591

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