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Copper-Catalyzed Borylacylation of Activated Alkenes with Acid Chlorides.

ABSTRACT: A method for the copper-catalyzed borylacylation of activated alkenes is presented. The reaction involves borylcupration of the alkene, followed by capture of the generated alkyl-copper intermediate with an acid chloride. The reactions operated with low catalyst loading and generally occurre within 15?min at room temperature for a range of activated alkenes. In the case of vinyl arenes, enantioselective borylacylation was possible.

SUBMITTER: Huang Y

PROVIDER: S-EPMC5708594 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Copper-Catalyzed Borylacylation of Activated Alkenes with Acid Chlorides.

Huang Yuan Y Smith Kevin B KB Brown M Kevin MK

Angewandte Chemie (International ed. in English) 20170918 43

A method for the copper-catalyzed borylacylation of activated alkenes is presented. The reaction involves borylcupration of the alkene, followed by capture of the generated alkyl-copper intermediate with an acid chloride. The reactions operated with low catalyst loading and generally occurre within 15 min at room temperature for a range of activated alkenes. In the case of vinyl arenes, enantioselective borylacylation was possible. ...[more]

PMID: 28849603

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