Ontology highlight
ABSTRACT:
SUBMITTER: Jafferali MH
PROVIDER: S-EPMC5709512 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Jafferali Mohammed Hakim MH Figueroa Ricardo A RA Hasan Mehedi M Hallberg Einar E
Scientific reports 20171130 1
Muscles are developed and regenerated in a differentiation process called myogenesis, which involves components of the nuclear envelope. We have investigated Samp1 (Spindle Associated Membrane Protein 1), a transmembrane nuclear envelope protein, which interacts with emerin and lamin A, both of which are linked to Emery-Dreifuss muscular dystrophy (EDMD). We found that the levels of Samp1 increased seven-fold during differentiation of mouse C2C12 muscle progenitor cells. To test if Samp1 could h ...[more]